Functional Groups ✏ Biology In a Nutshell




Functional Groups | In a nutshell

Many organic molecules have functional groups.

Each functional group confers on organic molecules properties such as acidity and polarity.


Hydroxyl(-OH) :  polarity, hydrophilic
e.g. Ethanol, Glycerol, Sugars

Carboxyl(-COOH) : polarity, hydrophilic, weak acid
e.g. Ethanoic acid, Amino acid, fatty acid

Amino(-NH₂) : polarity, hydrophilic, weak base
e.g. Amino acid

Phosphate(-PO₃²⁻) : polarity, hydrophilic, acid
e.g. ATP, DNA, Phospholipids

Carbonyl(-CO) : polarity, hydrophilic
e.g. Propanone, Sugars

Carbonyl(-CHO) : polarity, hydrophilic
e.g. Methanal, Sugars

Methyl(-CH₃) : non-polarity, hydrophobic
e.g. fatty acid, oil


Important functional groups

Hydrogen (-H)


Hydrogen is either polar or nonpolar, depending on the atom to which it is bonded; it is involved in condensation and hydrolysis.


Hydroxyl (-OH)



This functional group has polar properties; it is involved in condensation and hydrolysis.


Carboxyl (-COOH)


It is acidic, negatively charged when H+ dissociates, involved in peptide bonds


Amino (NH₂) 


It is basic and has the potential to bond an additional H+, thereby becoming positively charged and becoming involved in peptide bonds.

Methyl (CH₃)


It is nonpolar and contributes to the hydrophobicity of molecules.


Phosphate (H₂SO₄)


It is acidic, and when H+ dissociates, it can produce up to two negative charges, establishes a connection between the nucleotides in nucleic acids, can act as an energy carrier group in ATP.

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